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CAS No. 82571-53-7 | Ozagrel

Name: Ozagrel CAS No. 82571-53-7 MF:C13H12N2O2 MW:228.25 Purity:99% Package: 10g,25g,50g,100g,250g Worldwide Delivery

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Biochemicals

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Product introduction

Introduction and application of CAS No. 82571-53-7 | Ozagrel

Synonyms:(E)-4-(1-Imidazoylmethyl)cinnamicacid;

2-Propenoicacid,3-[4-(1H-imidazol-1-ylmethyl)phenyl]-,(2E)-;

(E)-3-[4-(1H-Imidazol-1-ylmethyl)phenyl]propenoicacid;

(E)-3-[p-(1H-Imidazol-1-ylmethyl)phenyl]acrylicacid;

3-[4-(1H-IMIDAZOL-1-YLMETHYL)PHENYL]-2E-PROPENOICACID;

OzagrelAPI;

Ozagrel(OKY-046);

(2E)-3-[4-(1H-imidazol-1-ylmethyl)phenyl]-2-propenoicacid

Specification:

ITEMS	SPECIFICATION
CAS	82571-53-7
MF	C13H12N2O2
MW	228.25
Melting point	223-224°
Boiling point	468.0±25.0 °C
Density	1.17±0.1 g/cm3
Acidity coefficient	4.43±0.10
Solubility	DMSO: 50 mg/mL (219.06 mM; requires ultrasound)
Form	Powder
Storage condition	Sealed in dry,Room Temperature

use:

Powerful thromboxane synthase inhibitor. By inhibiting thromboxane synthase, it reduces thromboxane A (TXA2) in the body and promotes the production of prostacyclin (PGl2) to combat platelet aggregation and cerebral vascular spasm, while it inhibits cyclooxygenase and other arachidonic enzymes. Acid metabolizing enzymes have little effect. It is clinically used to improve cerebral spasm after subarachnoid hemorrhage, cerebral ischemia symptoms associated with cerebral spasm, and movement disorders associated with the acute phase of cerebral thrombosis.

production method:

Using p-tolubenzaldehyde as the raw material, it undergoes aldol condensation with acetic anhydride and then dehydrates to generate 3-p-tolylacrylic acid, which is ethyl esterified into 3-p-tolylacrylic acid ethyl ester, and benzoyl peroxide is used as the initiator. Use N-bromosuccinimide (NBS) to brominate the methyl group on the ring to bromomethyl, then react with imidazole and then hydrolyze to form sodium ozagrel, with a melting point of 308°C (decomposition).

Package and transportation :

Package: 10g,25g,50g,100g,250g